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<p>Migraine is ranked by the World Health Organization (WHO) as the seventh most disabling disease and the leading cause of disability among all neurological disorders.</p>



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<p>Such is the severity of migraine in its harshest manifestation that the august body considers it to be as debilitating as quadriplegia, according to Dr Mark Weatherall, Consultant Neurologist at the Buckinghamshire Healthcare NHS Trust in the UK.</p>



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<p>“Now that sounds ridiculous on one level, but it is not really,” he says in a BBC podcast. “Because if you think about someone in the throes of a severe migraine attack, they are bedbound, they are vomiting, they can’t move, they can’t bear the light, they can’t bear the noise. They cannot do anything.”</p>



<h3 class="wp-block-heading">Widespread suffering</h3>



<p>Up to one billion people in the world are believed to suffer from migraine. The onset and causes of the disorder are thought to vary from person to person and the symptoms, likewise, differ considerably. A migraine may last for just a few minutes or as long as a few days, though several hours is often cited as common. Major symptoms include a throbbing head, nausea, dizziness and disturbed vision, yet any of the human senses can be affected, from phantom smells to tingling skin.</p>


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<p>Though conceding it is not a permanent disability, the headache specialist notes that the lives of people who have migraine daily or almost every day will be severely impacted. Carrying out normal routine activities or holding down a job may not be possible. Ultimately, acute migraine can wreck lives. Some sufferers have said they become emotionally withdrawn from family and friends.</p>



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<p>Until relatively recently, the condition has been little understood. It was not widely studied in the medical community, resulting in misdiagnosis. For instance, those struggling to find the right words for things during a migraine attack have been rushed to hospital with doctors suspecting stroke or a brain tumour.</p>



<h3 class="wp-block-heading">Hallucinatory hell</h3>



<p>Visual disturbance comes under a range of symptoms called the migraine aura, which occurs in about 20-30% of sufferers. Relating to the focal area of dysfunction in the brain, auras can be flashing lights, wavy lines or a much more complex hallucinatory experience. The latter can be terrifying for the migraineur in the first unknowing instances – that is, before the extent and intensity of the sensations have been fully explained to the sufferer.</p>



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<p>During an aura, some people feel an overwhelming sense of fatigue and have reported seeing hexagonal shapes as if they were looking through the eye of a fly. A simpler visual disturbance is photopsia, which consists of circles, triangles, squares and other geometric patterns, usually white or multicoloured.</p>


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<p>Although these can be seen in any part of the migraineur’s visual field, it is actually a trick of the perceptual imagination; the patterns and shapes are not there in reality. Their occurrence is most likely unrelated to the eye itself and caused by irritation of the vision centre of the brain. More complex and symmetrical patterns can sometimes be seen, and even the blind have been known to experience this disturbing phenomenon.</p>



<h3 class="wp-block-heading">Distorted perception</h3>



<p>Some disturbances are so bizarre that patients delay seeing a doctor for fear of being thought mentally ill. Objects can appear distorted and contorted in some types of visual aura, as if being visualised through a funhouse mirror; body proportions seem out of shape, necks become larger and legs look abnormally small. This is aptly called Alice in Wonderland syndrome since author Lewis Carroll was afflicted by migraine and used his bizarre hallucinatory attacks as inspiration to create Alice and her magical world.</p>



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<p>Changes in distance perceptions are also a feature of visual aura – how close or far away objects seem to the beholder could be totally unrelated to reality.</p>



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<p>Distortions of sensation or movement are characteristics of classic aura. Tingles or numbness on one side of the face and in the hands and arms can become alarming very quickly. Weakness and clumsiness can occur, while dizziness or abnormal sensations of motion or auditory misperceptions such as a ringing or crackling noise in the ears have been reported. For some sufferers, irritation in the part of the brain that handles memory also results in amnesia.</p>



<h3 class="wp-block-heading">Pulsating headaches</h3>



<p>Migraine headaches are divided into two subtypes – classic migraine which has the aforementioned aura, and common migraine which appears with no aura. They usually affect the frontal forehead region as well as the eyes – an initial pressing, gripping pain that later progresses to a throbbing, banging, pounding headache.</p>


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<p>While headaches can be absent altogether (silent migraine), in some cases they are agonisingly painful, affecting the person’s entire skull; their ferocious intensity can entice suicidal thoughts. The scalp can become very tender during a severe migraine attack and sneezing, coughing and vomiting can become extremely painful.</p>



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<p>People with a prolonged history of migraine headaches should seek professional support if their headaches do not fit a recognisable pattern, or when abnormal physical symptoms are apparent.</p>



<h3 class="wp-block-heading">Triggers of attack</h3>



<p>The exact cause of migraine is not clear, although spinal disorders, hormonal fluctuations, stress, fatigue, sleepless nights, certain odours, allergic reactions, glaring sunlight, diet, caffeine, exercise, levels of hydration, cigarette smoke and smoking itself have all been cited as contributory factors. Some people have even reported experiencing migraine headaches during sexual activity, especially at the moment of orgasm. For others, barometric pressure or altitude changes are believed to have triggered attacks. Avoidance of triggers may help, but attacks will usually still occur.</p>


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<p>Constriction of blood vessels was once theorised as a cause, but it is now thought that nerves in the body drive migraines. Weatherall notes that normal processes in the body dealing with sensory input go awry during a migraine attack. “You start to get signals sent out to the blood vessels around the head and the neck, and various neurochemicals are released. The lynchpin molecule, calcitonin gene-related peptide, is picked up by receptors around the blood vessels, which starts to generate pain. As that process continues, other networks start to become engaged that may make us feel nauseous or sensitive to light or noise,” he explains.</p>



<h3 class="wp-block-heading">Effective drugs</h3>



<p>Medical research conducted into ways to block or ease the transmission of overactive pain nerves has highlighted a relationship between serotonin, a chemical messenger in the brain, and migraine. The triptan family of drugs has demonstrated efficacy in halting migraine attacks by affecting serotonin receptors. These drugs are often prescribed to patients when other preventative medications, such as painkillers or beta blockers, fail to provide relief. By imitating the actions of serotonin, these drugs ease overactive pain nerves</p>



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<p>A major new study led by the University of Oxford and involving more than 89,000 people has found that triptans are the most effective medicine for adults experiencing acute migraine. It compared the effectiveness of 17 different oral medications often used to treat the condition. The results were published in The British Medical Journal this summer.</p>


Days in the dark: For migraine sufferers, recent drug research could afford bearable light at the end of the tunnel


<p>The collapse of Physical Fitness, one of the stalwarts of Hong Kong’s gym industry, was a shock to many of its loyal customers and those unfamiliar with the dynamics of the industry. It has left some wondering whether there are simply too many gyms in Hong Kong and if they provide value for money.</p>



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<p>Physical, which had operated in Hong Kong for 38 years and once boasted 23 branches, ceased trading this September after the Mandatory Provident Fund Schemes Authority demanded it settle unpaid contributions to more than 700 employees amounting to millions of dollars. The decision by the gym chain owners to close shop left staff jobless and triggered thousands of complaints to the Consumer Council over loss of membership fees. Some customers were on decade-long membership packages. There were also reports of lengthy packages sold just prior to its closure.</p>



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<p>Given the recent upsurge in investment in the sector, Physical’s failure did not come as a shock to many gym insiders. “I can’t say that Physical going under felt like a massive surprise,” says Ed Haynes, founder and CEO of boutique gym Coastal Fitness, who also made reference to some of the “amazing” deals the chain offered just before its ignominious collapse, perhaps in a desperate bid to cut its losses.</p>



<h3 class="wp-block-heading">Fall of the mighty</h3>



<p>Haynes notes this is the fourth big commercial gym operation to shut down during the 16-year lifespan of Coastal Fitness – on the heels of California Fitness in 2016, Goji Fitness and the Hong Kong branches of international chain Fitness First. The latter two faltered amid the pandemic, which interrupted business and made the recruitment of new members almost impossible.</p>



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<p>Certainly, many consumer discretionary sector businesses, including cafés, restaurants and cinemas as well as fitness centres, suffered financially during the Covid years. But the pandemic also had a benign influence on the fitness industry – people became worried about their health.</p>



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<p>“In the minds of the Hong Kong public, the idea of health and exercise came to the forefront a lot more,” says Haynes. “In the pandemic, when everything closed and people were confined to their homes in their small and immediate environments, a lot of people actually started exercising.”</p>



<h3 class="wp-block-heading">Gym crazy</h3>



<p>Since then, he has witnessed a huge upswing in many forms of physical activity practised in the community, which in turn has prompted a proliferation of investment in the industry. “Because the fitness industry saw this big boom in exercise participation, low-cost 24-hour gyms started popping up everywhere. And I think that’s almost saturated that market,” he states.</p>



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<p>From the less than 10 24-hour gyms believed to be operating in 2018, the number had ballooned to more than 110 by last year. Haynes believes too many gyms have opened up too quickly, causing supply to outpace demand. He also maintains that many of the newer gyms are soulless and lacking in a community feeling. “The way these gyms are set up is just you go in and do your hour; you’re isolated in many of them,” he opines.</p>



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<p>The pandemic not only sparked an increase in physical activity but also a desire for community-based fitness where people can connect with each other, according to Haynes: “If you go out to any of the waterfronts right now, every morning, every night, they are packed with groups of people in running clubs, sweating, moving, having a good time.”</p>



<h3 class="wp-block-heading">Cash flow precautions</h3>



<p>He also outlines a key learning curve in the gym business from the pandemic years: the importance of maintaining cash flow through offering membership packages. More than two-thirds of the Coastal Fitness membership sign up for six or 12 months in advance, providing money in the bank. The pay-when-you-use model adopted by some of the newer gyms, by contrast, does not give owners this security.</p>



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<p>Haynes has witnessed a rise since the pandemic in the purchase of long-term packages by clients willing to commit to regular exercise. He does caution against lengthy prepayment deals though; at Coastal Fitness 12 months is the maximum term offered.</p>



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<p>The majority of his clients come through referrals or word of mouth, and they include people from all walks of life. Most use the North Point gym’s services at least three times a week, and all receive some type of coaching, whether through attending a group class led by a coach, having a personal training session, or by following a tailored fitness programme designed by a coach.</p>



<h3 class="wp-block-heading">Operational stress</h3>



<p>During the post-pandemic investment splurge in the gym business, John Bower took on the managerial responsibilities of a new fitness start-up in Hong Kong. As an entrepreneur who had created and sold a human resources business earlier in his career, he seemed an ideal fit to launch the venture. However, the market glut in gyms soon exacerbated the stresses of running a fledgling operation, and breaking even took longer than planned. Exhausted, he quit after two years and now freelances as a personal trainer and executive coach.</p>



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<p>Bower believes the gym sector has been flooded with entrants and the next two years will favour the consumer. He says managers of gyms should be crystal clear what market they are going to dominate. “In the longer term, the harsh truth is that many gyms are on borrowed time and need to figure out their strategy – being number one in the local market and number 10 in Hong Kong might be fine,” he says.</p>



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<p>Far happier working as a freelance coach, he often conducts sessions for clients at the city’s many boutique gyms. He loves the interpersonal interaction with clients and can advise on all aspects of life aside from physical training. “The value of personal training is that it enables the client to physically challenge themselves,” he says.</p>



<h3 class="wp-block-heading">Market jitters</h3>



<p>Some gym-goers may be tempted to turn to personal instruction rather than sign up for memberships as fears over the stability of the wider fitness sector mount. Recent disputes over unpaid rent at branches of Pure Fitness, an upmarket chain of fitness and yoga studios, caused jitters in the market, although the issues were quickly resolved.</p>



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<p>Hong Kong-based lawyer and writer Sanjeev Aaron Williams chose not to join a well-known commercial gym after their sales pitch left him unclear about what the fees would cover. He now attends gyms run by the Leisure and Cultural Services Department. While available at a fraction of the price of many private gyms, these government fitness rooms have their drawbacks, says Williams, such as blackout periods restricting use and irregular availability of equipment.</p>



<h3 class="wp-block-heading">Essential regulation</h3>



<p>Williams sees a future for commercial gym operators, but calls for urgent government regulation. “Gyms in Hong Kong need to be regulated by legislation and monitoring. We are behind other countries in regulating consumer protection and gym operations,” he says. “Commercial gyms in Hong Kong have been the subject of failures and scams since the 1980s when the fitness trend began. We’ve gone over 40 years without regulated protection.”</p>



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<p>He believes any legislation should cover the entire fitness sector including large commercial gyms, 24-hour gyms, personal training studios, personal trainers, pilates and yoga studios, boxing and martial arts gyms, as well as the classes offered at these venues.</p>



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<p>The lawyer urges a limitation on the length of prepayments, saying they should not exceed more than two years, and calls for the implementation of a legal “cooling-off period [that] should be prominently advertised on the premises and to each customer”. He adds: “Consideration should be given to increasing criminal penalties for misleading advertising and sales tactics or carrying on business when [the operator] knew they couldn’t meet their debts.”</p>



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Fit for Purpose? Physical’s sudden demise spotlights a saturated gym sector in need of a work-over


<p>As American athlete Noah Lyles was wheeled off the track after securing bronze in the 200 metres at the Paris Olympics, the sheer exhaustion on his face said it all. Just moments later he revealed his Covid-19 diagnosis – he had kept it quiet beforehand so his competitors wouldn’t have the edge.</p>



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<p>This is a supreme athlete who only days previously had secured a fantastic gold medal in the 100 metres. Now, though, he was light-headed, short of breath and suffering from chest pains. Covid symptoms that more than likely would last a relatively short period of time.</p>
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<p>But what if they were to persist for months, if not years? Then Lyles would join the estimated 65 million people around the globe – including many formerly super-fit athletes – who have long covid. For these sufferers, whose symptoms can severely impact the quality of their daily life, the Covid-19 pandemic has never ended. Despite the amount of research invested in long covid, medical science appears far from finding a cure or pinpointing the cause of the debilitating condition.</p>



<h3 class="wp-block-heading">Lingering symptoms</h3>



<p>According to New Scientist, the term ‘long covid’ was used in medical circles as early as May 2020 to describe people whose covid symptoms lingered on. There are a multitude of continuing symptoms, but shortness of breath, brain fog and fatigue are most commonly cited, as well as post-exertional malaise – a feeling of exhaustion after just a short spurt of activity.</p>



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<p>The loose consensus among the medical community is that about 10% of people infected with the SARS-CoV-2 coronavirus suffer from long covid, says David Putrino, Director of Rehabilitation Innovation at the Mount Sinai Health System in New York and an expert in the condition. The figure is the subject of continued speculation, though, and the risk of long covid appears to depend upon the viral variant. Nevertheless, some studies have predicted that up to 200 million people will develop the condition over the next decade.</p>



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<p>The clinical definition of long covid is a persistence of Covid-19 signs and symptoms beyond four weeks; having persistent symptoms after 12 weeks that are not explained by an alternative diagnosis is deemed to be post Covid-19 syndrome – though, in practice, the two terms are often used interchangeably.</p>



<h3 class="wp-block-heading">Gut action</h3>



<p>There is no unifying theory of its cause, but rather a number of pervading theories that perhaps overlap. “One that is getting most traction is that the virus itself is hanging around in the body away from the immune system, most likely in the gut,” said David Strain, an Associate Professor at the University of Exeter Medical School, in a BBC podcast. “The virus is not getting into the blood on a regular basis, and when it does, it doesn’t get high enough to trigger any tests – [so] you aren’t going to show positive on a lateral flow test or a PCR test.”</p>



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<p>In this situation, when sufficient virus leaks intermittently into the blood, the person re-experiences a flu-like illness and becomes exhausted for no apparent reason.</p>



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<p>Another theory is that the infection causes a degree of permanent damage to the cell mitochondria. “The mitochondria are the powerhouse of every single cell, generating the energy you need to do any sort of activity,” says Strain. “When the virus gets into the cells, it uses the pathway that stimulates the production of mitochondria, [and doctors] are suggesting that the virus itself makes those mitochondria go dormant, which is why we run out of energy much quicker [resulting in] fatigue and brain fog.”</p>



<h3 class="wp-block-heading">Capillary blockage</h3>



<p>Micro-clotting is also being considered as a cause of long covid. As Dr Strain relates: “We know that covid causes small blood clots to form within the capillaries, the very, very small blood vessels within our body. If those small blood clots are blocking those capillaries, the body can’t get nutrients to the tissues that need them, and probably more importantly, it can’t get rid of waste products.</p>



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<p>This would explain why some people with long covid feel fine at the start of the day, when the body has had time to replenish itself, but become exhausted very quickly soon after. “It also accounts for why people who do some exercise will take two or three days to recover – post-exertion malaise – because those toxins build up and they aren’t clearing at the normal rate,” he reveals.</p>



<h3 class="wp-block-heading">Immune disruption</h3>



<p>As reported recently in New Scientist, there is a growing body of evidence pointing to disruption in the immune system of long covid sufferers. Studies have suggested some parts of their body develop an overactive immune system, while in other parts the immune system remains underactive. Other research indicates the existence of an autoimmune disorder in which the immune system attacks the body.</p>



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<p>Strain, however, is not so sure, since people with long covid appear to improve after receiving Covid-19 vaccinations. “If it was an autoimmune disease, the immune system ramps up [and] you may expect that vaccination to make it worse rather than better,” he notes.</p>



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<p>Evidence that the virus persists in many parts of the body – tissues and organs, gut lining, skin and lungs – has highlighted the similarities between this and other chronic conditions such as myalgic encephalomyelitis (ME), or chronic fatigue syndrome. Strain believes it is likely that ME and long covid belong to the same family of conditions but have different underlying triggers.</p>



<h3 class="wp-block-heading">Brain energy drain</h3>



<p><br>Brain fog is one of the symptoms reported by sufferers of long covid. This is where people have difficulty concentrating, perhaps even struggling to get to the end of a sentence. Strain says this brain fog could stem from a lack of energy reaching the brain, though some studies suggest the virus may have caused significant brain injury.</p>



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<p>A 2022 study in the UK involving 800,000 people explored the cognitive effects of Covid-19. On average, people who had covid for more than 12 weeks or had required hospital treatment performed worse in the cognitive tests. Even those who had symptoms for less than 12 weeks did worse than the no-confirmed-infection group. People infected early in the pandemic were shown to be among the poorest performers. This could be attributed to the effects of vaccinations and other variants coming into play.</p>



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<p>Ultimately, many questions about the long-term consequences of Covid-19 infection on the brain remain unanswered. Separate research has suggested low levels of serotonin, a neurotransmitter, could explain cognitive symptoms that occur in long covid.</p>



<h3 class="wp-block-heading">Treatment conundrum</h3>



<p>Long covid is undoubtedly a nightmare to treat because of the huge degree of uncertainty surrounding the condition and the large number of different presentations. There is no test for long covid and it could be years of clinical trials before practitioners know how best to treat it.</p>



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<p>Existing treatment methods include recurrent boosts of vaccines and laboratory-made antibodies to top up the immune system. Long-covid specialists advise those affected to seek a thorough assessment supplemented by a range of treatment options from psychological support to medication.</p>


Viral Load: For millions weighed down by covid symptoms, there has been no relief


<p>The bustling metropolis of Hong Kong, known for its towering skyscrapers and densely packed streets, has long been praised for its robust public transportation system. However, the true gem of this vibrant city may lie in its often-overlooked yet invaluable network of walkable pavements. As the world grapples with the rising prevalence and associated health concerns of sedentary lifestyles, our sidewalks have emerged as a beacon of hope, offering residents a tangible path towards a healthier future.</p>



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<p>Recognising the vital role of foot travel in shaping a liveable and sustainable city, the Hong Kong Transport Department has spearheaded a comprehensive strategy to deliver a walkable urban haven. Unveiled in 2020, the Walk in HK initiative has placed pedestrians at the forefront of transportation planning, fostering a walk-friendly environment that encourages residents and visitors alike to embrace the simple joy of strolling about town.</p>


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<p>“Walkability is not just about connecting destinations,” says the Transport Department on its website. “It’s about creating an urban ecosystem that promotes physical activity, social interaction and environmental sustainability – all of which are essential for the well-being of the community.”</p>



<h3 class="wp-block-heading">Walkways &amp; Means</h3>



<p>A key aspect of Walk in HK has been the provision of cover to the city’s often elevated and interconnected walkways. This has seen the government work closely with District Councils to identify strategic locations for the installation of canopies. Sheltered pathways not only shield pedestrians from the elements but also provide a more comfortable and inviting experience for exploring the city on foot.</p>



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<p>Pedestrians have also been empowered by widened pavements, raised crossings on roads and the removal of non-essential roadside railings and traffic signage. Meanwhile, a new wayfinding signage system has eased the risk of losing one’s way in the maze of city streets.&nbsp;</p>



<h3 class="wp-block-heading">Stepping Stone to Health</h3>



<p>The importance of physical activity for overall well-being is well-documented, and Hong Kong’s walkable streets provide the perfect avenue for residents to incorporate more movement into their daily routines. From the bustling Central district to the serene seaside promenades, these pedestrian-friendly pathways encourage residents to trade in their car keys or public transport passes for a more active mode of transportation.</p>



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<p>“Walking has become an integral part of my daily life,” says local resident Rebeca Pangan. “The seamless connectivity of the sidewalks allows me to walk to work easily, run errands, and even explore the city’s hidden gems without the hassle of traffic or parking.”</p>



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<p>The benefits of pedestrianism extend beyond physical health. Studies have shown that regular physical activity and walking can not only reduce the risk of chronic diseases but also have a profound impact on mental well being, stress, anxiety and depression, as well as cultivate stronger social connections within the community. The city’s diverse streetscapes, from bustling commercial hubs to serene green spaces, provide a calming respite from the fast-paced urban environment, allowing residents to clear their minds and find moments of tranquillity.</p>



<h3 class="wp-block-heading">Strolling Players&nbsp;</h3>



<p>“Taking a stroll along the Sai Wan Pier, what we locals call the ‘Instagram Pier’, has become my daily ritual,” shares regular walker Jack Fontanilla. “The gentle sea breeze and picturesque views of the harbour not only energise me physically but also provide a much-needed mental refresh amid the demands of daily life. Plus, it benefits my social media page.”</p>



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<p>Hong Kong’s commitment to walkable infrastructure is evident in well-designed and user-friendly areas throughout the city. One standout example is the iconic Central-Mid-Levels Escalator, which at more than 800 metres in length is the world’s longest outdoor covered escalator system. Opened in 1993, it allows commuters to navigate the hilly terrain between the central business district and residential Mid-levels without breaking a sweat.</p>



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<p>Another gem is the Tsim Sha Tsui Promenade, a picturesque waterfront walkway that offers stunning views of the Hong Kong skyline and Victoria Harbour. Its wide, well-maintained pavement provides a tranquil escape from the bustling streets, attracting both locals and visitors alike to stroll, jog, or simply take in the scenery.</p>



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<p>The Sai Ying Pun neighbourhood, with its vibrant street life and carefully planned pedestrian infrastructure, is another shining example of Hong Kong’s dedication to walkable urban design. The area’s narrow streets, flanked by diverse shops and eateries, create a pedestrian-friendly environment that encourages residents to explore on foot, fostering a sense of community and social interaction.</p>



<h3 class="wp-block-heading">Jolly Walkers</h3>



<p>Once a largely industrial area, Kwun Tong has undergone a remarkable transformation in recent years, with the development of the Kwun Tong Promenade being a true highlight. This expansive waterfront green space has breathed new life into the community. Extending for a kilometre, the promenade hugs the shoreline, providing breathtaking views of the harbour, lush greenery, meandering walkways and serene rest areas for a harmonious balance between nature and urban elements. People of all ages are often seen out for a stroll, chatting with neighbours, or even participating in group exercises. It’s a testament to the power of well-designed pedestrian infrastructure to bring people together.</p>



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<p>Other spots that should make everyone’s list of the must-see walking trails of urban Hong Kong are the Central Waterfront Promenade, Li Yuen Street East and West and Aberdeen Street in Central, Art Square at Salisbury Garden on the Tsim Sha Tsui waterfront, and the West Kowloon Cultural District. Those with time to walk outside of the city limits could head for Lugard Road to circle the Peak or take the Mills &amp; Chung Path linking Ocean Park and Deep Water Bay, then stroll along the Seaview Promenade to Repulse Bay. Further away are the Bones of Miss Willy at Cape D’Aguilar, Tung Ping Chau Marine Park and Lok Ma Chau Lookout in the New Territories, and Shek Tsai Po Street Promenade and Sunny Bay on Lantau Island.</p>



<h3 class="wp-block-heading">Striding Ahead</h3>



<p>As Hong Kong continues to evolve and adapt to the changing needs of its residents, the focus on walkable pavements remains a top priority for the Transport Department. By weaving pedestrian-friendly elements into both new developments and existing urban areas, the city is poised to reap the myriad benefits of a more walkable future – from improved public health to enhanced liveability and community cohesion.</p>



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<p>As the Transport Department shares: “We’re committed to creating a Hong Kong where walking is not just a means of transportation, but a joyful and enriching experience. By empowering people to explore their city on foot, we’re paving the way for a healthier, more connected and more sustainable future for all.”</p>


Walk This Way: The route to a healthier, happier and more connected community, one step at a time…


<p>Anxiety, an increasing concern in recent years particularly among young people, is detrimental to health, but what if it is excessive worry about your health that troubles you? Exaggerated feelings of unease about having or developing a serious undiagnosed medical condition are nothing new. The Greek physician Hippocrates first used the word hypochondria in the fifth century BCE, and it has been the subject of discussion and study through every era since, with a vast and bewildering literature dedicated to the subject.</p>



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<p>Around the 17th century, hypochondria had come to denote a mysterious and melancholy condition thought to result in an imbalance in the organs of the abdomen; then gradually, it was used to refer to any illness without a detectable cause. It is generally considered shorthand for an illness that is all in your head.</p>


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<p>Hypochondriasis is a psychiatric disorder with very specific diagnostic criteria. Health anxiety is a much broader term used today to describe such conditions, which can encompass depression, various anxiety disorders, chronic illness and pain, among other problems.</p>



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<p>A diagnosis of hypochondriasis or illness anxiety disorder usually entails the following: a preoccupation with a fear of having a serious disease based on misinterpreting the meaning of physical symptoms, which persists despite medical tests showing nothing is wrong and reassurance from doctors, is present for at least six months, and is not focused exclusively on a concern about physical appearance; and an awareness on some level that this fear may not be 100% accurate.</p>



<h3 class="wp-block-heading">Personal battle</h3>



<p>British writer Caroline Crampton lives in constant fear that there is something seriously wrong with her. In a moving and heartrending story of a hypochondriac in the throes of despair, she details her personal battle with the debilitating condition.</p>



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<p>It all began when she was 17 and developed blood cancer, which was only discovered after a tumour had appeared on her neck. Following several gruelling rounds of chemotherapy, she was given the all-clear, but even though she was cured, she became ever-alert to potential new symptoms, constantly worrying that the cancer may have returned. “The fear that there is something wrong with me, that I am sick, is always with me,” she says in a BBC podcast of her memoirs called A Body Made of Glass.</p>



<div class="wp-block-media-text alignwide is-stacked-on-mobile"><figure class="wp-block-media-text__media"><img decoding="async" loading="lazy" width="683" height="1024" src="https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-4016610-683x1024.jpg" alt="" class="wp-image-82862 size-full" srcset="https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-4016610-683x1024.jpg 683w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-4016610-187x280.jpg 187w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-4016610-768x1152.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-4016610-1024x1536.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-4016610-1365x2048.jpg 1365w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-4016610-200x300.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-4016610-800x1200.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-4016610-scaled.jpg 1707w" sizes="(max-width: 683px) 100vw, 683px" /></figure><div class="wp-block-media-text__content">
<p>She tells of a bus journey “half listening to somebody else’s phone call, when I suddenly went deaf”. Her heart beat faster and faster as the fear grew stronger, and her vision blurred into “a sparkling circle of refracted rays”. This sudden loss of hearing and sight happened three more times that week. “There was no pattern to it. I saw a nutritionist, a neurologist, a urologist, a cardiologist, a psychiatrist and an endocrinologist,” she shares.</p>
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<h3 class="wp-block-heading">Contradictory fears</h3>



<p>None of her tests showed anything unusual, so she had an MRI. As she lay motionless in the machine, she oscillated between two contradictory hopes: “I really wanted the scan to find something, so that I would have a name to put to my symptoms, and I was terrified that it would deliver the devastating news that I had some life-altering illness.”</p>



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<p>Another disturbing thought niggled at her, could she even be satisfied with the results, or would her impulse toward hypochondria convince her that there was something else lurking unseen just out of reach?</p>



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<p>The scan revealed nothing of concern, and this was the end of the road diagnostically. The answer to the baffling question of her hearing and vision problems was never discovered. She was given a small daily dose of a medication for low blood pressure, which reduced the number of episodes from several a week to just a few a year. “I still take this pill every day, dutifully refilling the prescription every month, despite having no idea why I am doing so or what malfunction of my body it is treating,” she says.</p>



<h3 class="wp-block-heading">Nothing is wrong</h3>



<p>Crampton has lost count of the number of times that she has been to the doctor only to be told the best thing to do is nothing at all. “This is hard advice to receive; the human craving for satisfying narrative demands an explanation for our suffering. Do something it screams – make an appointment, swallow a pill, take a test.”</p>



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<p>It took her a long time to entertain the idea that she might be a hypochondriac. It was much easier for her to see in hindsight. She had been encouraged by doctors to pay close attention to how she was feeling, in case she could pick up on an early warning sign of recurrence of her cancer.</p>



<figure class="wp-block-image size-large"><img decoding="async" loading="lazy" width="1024" height="683" src="https://www.gafencushop.com/wp-content/uploads/2024/08/MUST-INCLUDE-1-1024x683.jpg" alt="" class="wp-image-82860" srcset="https://www.gafencushop.com/wp-content/uploads/2024/08/MUST-INCLUDE-1-1024x683.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/08/MUST-INCLUDE-1-420x280.jpg 420w, https://www.gafencushop.com/wp-content/uploads/2024/08/MUST-INCLUDE-1-768x512.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/08/MUST-INCLUDE-1-1536x1024.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2024/08/MUST-INCLUDE-1-2048x1365.jpg 2048w, https://www.gafencushop.com/wp-content/uploads/2024/08/MUST-INCLUDE-1-200x133.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/08/MUST-INCLUDE-1-800x533.jpg 800w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure>



<p>Following her all-clear, she gradually came to realise that her level of interest in her fluctuating state of wellness was far from the norm. The sheer variety of procedures she had undergone had given her a level of comfort with the rarer elements of medicine that was unusual.</p>



<h3 class="wp-block-heading">Good at being unwell</h3>



<p>“More than that though, the awareness crept up on me that I spent much more time and effort on this aspect of life than anyone else I knew, even though I supposedly had no active conditions requiring treatment. At some point, my responsible cancer survivor behaviour had morphed into something else. Rather than worrying about actual developments with my illness, the worry itself had become the problem,” she reveals.</p>



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<p>“And it feels at times like having cancer for real was the training I went through so I could have a dozen other illnesses in my imagination. I am now very good at being unwell. I have had a lot of practice.”</p>



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<p>She believes most people have some legitimate concern about at least one aspect of their health, whether it is a prior condition, a family history or an environmental factor. “Hypochondria creeps in when this justifiable anxiety expands well beyond the boundaries of the verifiable health concern. For example, when someone with a chronic back injury becomes convinced that they have mouth cancer.”</p>



<h3 class="wp-block-heading">Safety and avoidance</h3>



<p>People with elevated levels of health anxiety are known to rely on safety behaviours or often avoid feared situations. Safety behaviours may include seeking reassurance from family and friends, doctors, medical books or the Internet; requesting frequent unnecessary medical tests; and monitoring physical symptoms, such as pain, racing heart, dizziness or blurred vision.</p>


<div class="wp-block-image">
<figure class="aligncenter size-large"><img decoding="async" loading="lazy" width="683" height="1024" src="https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-5430077-683x1024.jpg" alt="" class="wp-image-82863" srcset="https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-5430077-683x1024.jpg 683w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-5430077-187x280.jpg 187w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-5430077-768x1152.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-5430077-1024x1536.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-5430077-1365x2048.jpg 1365w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-5430077-200x300.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-5430077-800x1200.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/08/pexels-khoa-vo-2347168-5430077-scaled.jpg 1707w" sizes="(max-width: 683px) 100vw, 683px" /></figure></div>


<p>Alternatively, some people with a form of health anxiety avoid feared stimuli, which keeps their fear alive over the longer term. They may put off medical tests or seeing a doctor, or talking to others about health, illness or a feared disease. Experts suggest these strategies are counterproductive and advise confronting feared situations directly, and accepting feelings of anxiety and fear rather than trying to control them.</p>



<h3 class="wp-block-heading">Symptom management</h3>



<p>There are no straightforward answers to this chronic mental illness. Cognitive behavioural therapy, stress management and mindfulness techniques, such as meditation, may help manage symptoms.</p>



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<p>The impact of the Covid pandemic has lifted already rising rates of hypochondria, and a study in Norway has shown that high levels of anxiety about one’s own health can increase the risk of heart disease by up to 70%. As Crampton observes: “It would seem that worrying about being ill can, in fact, make you ill.”</p>


Ill Feeling: Hypochondria is a living hell for those whose profound fears about their health cannot be relieved 


<p>Food plays a powerful role in developing a strong and resilient immune system. This simple fact means we can boost our immune system through what we eat.</p>



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<p>This is vital as the immune system plays a powerful role in the maintenance of our health. It helps protect us from infections caused by viruses and other harmful microbes. If a person has weak or compromised immunity, it can have severe consequences. A healthy immune system, for instance, can identify tumours as foreign and may be able to contain or destroy cancerous cells.</p>


<div class="wp-block-image">
<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-solareflares-2751755-768x1024.jpg" alt="" class="wp-image-82428" width="384" height="512" srcset="https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-solareflares-2751755-768x1024.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-solareflares-2751755-210x280.jpg 210w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-solareflares-2751755-1152x1536.jpg 1152w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-solareflares-2751755-1536x2048.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-solareflares-2751755-200x267.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-solareflares-2751755-800x1067.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-solareflares-2751755-scaled.jpg 1920w" sizes="(max-width: 384px) 100vw, 384px" /></figure></div>


<p>Thus, aside from doing regular exercise and avoiding alcohol, drugs and a stressful lifestyle, for optimum health we should succour our immunity with foods that are known to play a vital role in upping our ability to combat disease and infection.</p>



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<p>Scientists are developing a clearer picture of the role food plays, and doctors are even prescribing certain foods as medicine – clinics and health organisations in various countries offer low-income groups produce prescription programmes so they can boost their intake of fruit and vegetables. Some nutritionists are now selling so-called immunity cubes – small ice cubes packed with immune-boosting ingredients – and advocating them as part of the daily diet.</p>



<h3 class="wp-block-heading">Healthy defence</h3>



<p>A basic understanding of the immune system is valuable to health. According to New Scientist, our innate immune system is the body’s first line of defence against pathogens. It responds rapidly to general threats and can distinguish between different classes of pathogens to recruit the most effective form of adaptive immune response to eliminate them. Providing an immunological memory of the threats we have faced, it enhances our future immune responses and builds a specialised defence system.</p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/07/Immunity-Cubes-820x1024.jpg" alt="" class="wp-image-82427" width="410" height="512" srcset="https://www.gafencushop.com/wp-content/uploads/2024/07/Immunity-Cubes-820x1024.jpg 820w, https://www.gafencushop.com/wp-content/uploads/2024/07/Immunity-Cubes-224x280.jpg 224w, https://www.gafencushop.com/wp-content/uploads/2024/07/Immunity-Cubes-768x959.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/07/Immunity-Cubes-1229x1536.jpg 1229w, https://www.gafencushop.com/wp-content/uploads/2024/07/Immunity-Cubes-200x250.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/07/Immunity-Cubes-800x999.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/07/Immunity-Cubes.jpg 1408w" sizes="(max-width: 410px) 100vw, 410px" /></figure></div>


<p>T-cells, which attack invading pathogens and infected cells, form part of the adaptive immune response. These lymphocytes can act as ‘helper cells’ by supporting B-cells to produce antibodies. B-cells are involved in both the innate and adaptive immune system and are responsible for mediating the production of antibodies against specific threats. Antibodies recognise specific antigens – a molecule from foreign material such as a virus or pollen grain that adheres to a specific antibody or T-cell – and bind to them as a way of tagging the unwanted object for attack by the rest of the immune system.</p>



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<p>Alternatively, antibodies can neutralise foreign material directly. Natural killer (NK) cells – white blood cells that form part of the innate immune system and provide a rapid response to viruses and other pathogens – are important players here.</p>



<h3 class="wp-block-heading">Balanced immunity</h3>



<p>A key aspect of a healthy immune system is to strike a balance between reactivity – such as warding off infection by detecting and killing bacteria, viruses, fungi and parasites – and restraint. The latter is required as the immune system can overreact when internal checks are compromised, causing it to attack the body’s own cells and proteins.</p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/07/Fremented-1024x576.jpg" alt="" class="wp-image-82425" width="768" height="432" srcset="https://www.gafencushop.com/wp-content/uploads/2024/07/Fremented-1024x576.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fremented-498x280.jpg 498w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fremented-768x432.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fremented-1536x864.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fremented-2048x1152.jpg 2048w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fremented-200x112.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fremented-800x450.jpg 800w" sizes="(max-width: 768px) 100vw, 768px" /></figure></div>


<p>This is often the case with people who have allergies; their immune system overreacts to harmless foreign substances like pollen and peanuts and these overreactions can lead to chronic low-level inflammation and cause debilitating conditions and accelerate the ageing process.</p>



<h3 class="wp-block-heading">Microbe management</h3>



<p>Scientists now know that the digestive tract is at the heart of the immune system. The largest immune organ in the body, the gastrointestinal tract has to sift through and cope with oodles of foreign bodies and microbes on a daily basis, sorting out the helpful from the harmful. Some microbes make us ill, while many more are crucial for our health. The immune system is in regular contact with trillions of microbes living in the gut, and from this communication, signals are sent to instruct the ramping up or down of gut activity.</p>



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<p>The vast microbiome inside our gut is the all-important bacterial community for stimulating the immune system. This vital link between gut microbiota and immunity became clear in a 2020 study by the Memorial Sloan Kettering Cancer Centre in New York, which showed for the first time that the concentration of different types of immune cells in the blood changes in relation to the presence of different bacterial strains in the gut.</p>



<h3 class="wp-block-heading">Powerful foods</h3>



<p>Furthermore, research has revealed that food plays a vital role in our gut ecology. Given the important function this organ plays in our health, it is heartening to know that scientists believe the delicate balance of the immune system can be modified naturally through diet. As the composition of our microbiome can redress chronic inflammation, any dietary intervention could be critical.</p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/07/Fruits-1024x576.jpg" alt="" class="wp-image-82426" width="768" height="432" srcset="https://www.gafencushop.com/wp-content/uploads/2024/07/Fruits-1024x576.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fruits-498x280.jpg 498w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fruits-768x432.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fruits-1536x863.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fruits-2048x1151.jpg 2048w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fruits-200x112.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/07/Fruits-800x450.jpg 800w" sizes="(max-width: 768px) 100vw, 768px" /></figure></div>


<p>Numerous studies have highlighted the correlation between diverse, immune-healthy gut microbiota and a high-fibre diet containing vegetables, whole grains and lettuce. The likes of leeks, onion, artichokes, soybeans and cabbage are particularly rich in a variety of fibre that provides nourishment for beneficial bacteria. Other prebiotic foods with special plant fibres that help healthy bacteria grow in the gut include garlic, asparagus, chicory and bananas. It is also possible to take prebiotic supplements.</p>



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<p>Foods such as green, leafy vegetables that dampen any inflammation after meals are thought to be vital in boosting the immune system. A team at King’s College London discovered people who regularly eat a lot of vegetables had lower levels of circulating white blood cells, resulting in fewer bouts of chronic inflammation and lower risk of chronic disease.</p>



<h3 class="wp-block-heading">Fermentation focus</h3>



<p>Consuming fermented foods such as kimchi, miso or yoghurt that contain helpful probiotics also plays a role in developing microbiome diversity and decreased inflammation markers. Probiotics are live cultures of the good bacteria normally found in your intestine. They can benefit your health by improving the balance of your gut bacteria and alleviating the harmful effects on the gut of poor diet, stress, ageing, infection or antibiotic use. A popular form is kefir, a fermented milk drink that can contain a billion bacteria. Probiotics are also available as tablets, capsules or sachets which can be added to a range of foods.</p>


<div class="wp-block-image">
<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-wendywei-1656663-1024x684.jpg" alt="" class="wp-image-82430" width="768" height="513" srcset="https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-wendywei-1656663-1024x684.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-wendywei-1656663-419x280.jpg 419w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-wendywei-1656663-768x513.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-wendywei-1656663-1536x1026.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-wendywei-1656663-2048x1368.jpg 2048w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-wendywei-1656663-200x134.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/07/pexels-wendywei-1656663-800x534.jpg 800w" sizes="(max-width: 768px) 100vw, 768px" /></figure></div>


<p>A note of caution regarding prebiotic and probiotic supplements comes from Justin Sonnenburg of Stanford University in California, who has said “very few things are solved just by popping a pill”. The professor of microbiology and immunology believes the most important factor in keeping your natural defences in good shape and maintaining a healthy gut is the overall composition of your diet.</p>



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<p>Ultimately, foods containing essential vitamins and minerals such as vitamins A, C, D and E, as well as some of the B vitamins, plus zinc, copper, selenium, magnesium and iron will help provide micronutrients to support the immune system. Fresh raw fruit and vegetable are the best sources of vitamin C, and pulses, shellfish and unrefined cereal provide zinc. In essence, immune-boosting foods are thought to be gut-friendly foods that help microbes do a more effective job in safeguarding the immune system.</p>


Gut Reaction: Nourishing your immune system with plant fibre and fermented foods fights inflammation and ill health


<p>The desire to keep one’s youth and vitality by defying the natural ageing process is not a recent phenomenon. While it may not be as old as the hills, it probably spans the existence of humankind. This Peter Pan-like urge to stop the march of time has long been the subject of popular culture. In the 1959 horror film The Man Who Could Cheat Death, a centenarian artist and scientist in 1890 Paris maintains his youth and health by transplanting parathyroid glands from the necks of the living. Another film, Orlando (1992), based on the Virginia Woolf novel, depicts a nobleman’s struggles to find his place in the world after being ordered not to grow old by Queen Elizabeth I.</p>



<h3 class="wp-block-heading">Cognitive concerns</h3>



<p>The subject of age has dominated the US presidential election campaign, with both Joe Biden, 81, and Donald Trump, 77, accused of being too old for the job. Critics point to the inevitability of age-related mental decline and forgetfulness, and attribute their gaffes, such as getting names mixed up, to their advanced years. Some analysts have suggested this is unfair, given the enormous pressure they are under and the constant scrutiny they are subjected to. In these circumstances, occasional misspeaking is to be expected.</p>



<div class="wp-block-media-text alignwide is-stacked-on-mobile"><figure class="wp-block-media-text__media"><img decoding="async" loading="lazy" width="819" height="1024" src="https://www.gafencushop.com/wp-content/uploads/2024/03/Laura-Germine2_p-819x1024.jpg" alt="" class="wp-image-80825 size-full" srcset="https://www.gafencushop.com/wp-content/uploads/2024/03/Laura-Germine2_p-819x1024.jpg 819w, https://www.gafencushop.com/wp-content/uploads/2024/03/Laura-Germine2_p-224x280.jpg 224w, https://www.gafencushop.com/wp-content/uploads/2024/03/Laura-Germine2_p-768x960.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/03/Laura-Germine2_p-200x250.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/03/Laura-Germine2_p-800x1000.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/03/Laura-Germine2_p.jpg 1121w" sizes="(max-width: 819px) 100vw, 819px" /></figure><div class="wp-block-media-text__content">
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<figure class="wp-block-image size-large"><img decoding="async" loading="lazy" width="819" height="1024" src="https://www.gafencushop.com/wp-content/uploads/2024/03/Joshua-Hartshorne_p-819x1024.jpg" alt="" class="wp-image-80824" srcset="https://www.gafencushop.com/wp-content/uploads/2024/03/Joshua-Hartshorne_p-819x1024.jpg 819w, https://www.gafencushop.com/wp-content/uploads/2024/03/Joshua-Hartshorne_p-224x280.jpg 224w, https://www.gafencushop.com/wp-content/uploads/2024/03/Joshua-Hartshorne_p-768x960.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/03/Joshua-Hartshorne_p-1229x1536.jpg 1229w, https://www.gafencushop.com/wp-content/uploads/2024/03/Joshua-Hartshorne_p-1639x2048.jpg 1639w, https://www.gafencushop.com/wp-content/uploads/2024/03/Joshua-Hartshorne_p-200x250.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/03/Joshua-Hartshorne_p-800x1000.jpg 800w" sizes="(max-width: 819px) 100vw, 819px" /></figure>
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<p>Furthermore, the science of ageing is uncertain. Research in cognitive function by Joshua Hartshorne of Boston College and Laura Germine from the McLean Institute for Technology in Psychiatry suggests it is no myth that wisdom increases with age. Older people tend to have the ability to see the big picture better than their youthful counterparts, though not necessarily the capability to recall specific facts instantly. The former skill is essential for a politician – a greater grasp of the wider historical context of world events would enable more informed decision-making. On the flip side, some studies have shown that tasks involving short-term memory decline from as early as 20 years old. To add to the complicated picture, arithmetic and comprehension skills, plus vocabulary, are thought to keep improving until 50, then decline thereafter.</p>



<div class="wp-block-media-text alignwide is-stacked-on-mobile"><figure class="wp-block-media-text__media"><img decoding="async" loading="lazy" width="819" height="1024" src="https://www.gafencushop.com/wp-content/uploads/2024/03/Jay-Olshansky_p-819x1024.jpg" alt="" class="wp-image-80823 size-full" srcset="https://www.gafencushop.com/wp-content/uploads/2024/03/Jay-Olshansky_p-819x1024.jpg 819w, https://www.gafencushop.com/wp-content/uploads/2024/03/Jay-Olshansky_p-224x280.jpg 224w, https://www.gafencushop.com/wp-content/uploads/2024/03/Jay-Olshansky_p-768x960.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/03/Jay-Olshansky_p-1229x1536.jpg 1229w, https://www.gafencushop.com/wp-content/uploads/2024/03/Jay-Olshansky_p-1638x2048.jpg 1638w, https://www.gafencushop.com/wp-content/uploads/2024/03/Jay-Olshansky_p-200x250.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/03/Jay-Olshansky_p-800x1000.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/03/Jay-Olshansky_p.jpg 1800w" sizes="(max-width: 819px) 100vw, 819px" /></figure><div class="wp-block-media-text__content">
<p>Jay Olshansky of the University of Illinois believes the two main contenders’ well-to-do backgrounds and family history of longevity work in their favour in terms of the ageing process and their expected lifespan.</p>
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<p>An article published in The Hill in January states that both Biden and Trump have higher than average expected chances for men of their age of surviving another presidential term. Olshansky also opines that some of Biden’s gaffes have been blown out of proportion. For instance, when he was captured falling off his bike in June 2022, many deemed it a sign of his physical decline and poor balance. However, a closer examination of the circumstances indicated that he had caught his foot in the pedal strap, something anyone could do. The pertinent point here is that Biden, then aged 79, was comfortably able to ride a bike in the first place – not that he got his foot caught.</p>



<h3 class="wp-block-heading">Survival of the fittest</h3>



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<p>Some people are chasing the anti-ageing dream far beyond the normal advice to reduce their weight, exercise and sleep more, quit smoking and limit alcohol intake. American entrepreneur Bryan Johnson, who made a fortune selling his electronics payments company Braintree to PayPal, reportedly spends US$2 million a year attempting to stop the biological clock. </p>
</div><figure class="wp-block-media-text__media"><img decoding="async" loading="lazy" width="768" height="960" src="https://www.gafencushop.com/wp-content/uploads/2024/03/nutritious-food.jpg" alt="" class="wp-image-80826 size-full" srcset="https://www.gafencushop.com/wp-content/uploads/2024/03/nutritious-food.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/03/nutritious-food-224x280.jpg 224w, https://www.gafencushop.com/wp-content/uploads/2024/03/nutritious-food-200x250.jpg 200w" sizes="(max-width: 768px) 100vw, 768px" /></figure></div>



<p>An all-over skin laser treatment is said to have reduced the 46-year-old’s skin age by 22 years, and he is known to observe a vigorous daily exercise routine and a strict plant-based diet including eating a kilogram of vegetables before 11 am, his usual dinnertime. He also consumes some 100 tablets a day, including the diabetes drug metformin and the immunosuppressant rapamycin, both hailed by longevity enthusiasts as ‘miracle’ anti-ageing pills.</p>



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<p>Described as the most measured man in the world, Johnson’s biological and chronological age are continually tracked and monitored. His aim is to reverse his measured biological age by more than one year for every one year that passes – the first stage of longevity escape velocity in which life expectancy increases faster than time passes.</p>



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<p>Confident his tortuous routine is paying dividends, he describes how he has near undetectable levels of inflammation, perfect blood pressure for his demographic, the ideal range of vitamin C, vitamin K, coenzyme Q10, 1GF-1 (insulin-like growth factor 1) and LDL (low-density lipoprotein) cholesterol, and a DHEA-S hormone level of someone aged 27. Just as impressively, in a series of physical tests, he scored equivalent to the top 10% to 25% of 18-year-olds.</p>



<h3 class="wp-block-heading">Supplement strides</h3>



<p>Johnson is now selling a basic version of his Blueprint protocol – described on his website as ‘The Most Nutritious Program in History’ – to those interested in adopting what he considers to be the perfect diet for the body. The idea that caloric restriction can significantly extend lifespan as long as all the necessary nutrients are ingested via minerals and vitamins is not new. It was advocated by the late Roy Walford, a professor of pathology at the University of California, among others, and their findings helped spawn the plethora of mineral supplements on the market.</p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/03/Roy-Walford_p-819x1024.jpg" alt="" class="wp-image-80827" width="410" height="512" srcset="https://www.gafencushop.com/wp-content/uploads/2024/03/Roy-Walford_p-819x1024.jpg 819w, https://www.gafencushop.com/wp-content/uploads/2024/03/Roy-Walford_p-224x280.jpg 224w, https://www.gafencushop.com/wp-content/uploads/2024/03/Roy-Walford_p-768x960.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/03/Roy-Walford_p-1229x1536.jpg 1229w, https://www.gafencushop.com/wp-content/uploads/2024/03/Roy-Walford_p-1638x2048.jpg 1638w, https://www.gafencushop.com/wp-content/uploads/2024/03/Roy-Walford_p-200x250.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/03/Roy-Walford_p-800x1000.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/03/Roy-Walford_p-scaled.jpg 2048w" sizes="(max-width: 410px) 100vw, 410px" /></figure></div>


<p>Though their life-extending capacity for humans is open to question, some supplements are generating considerable interest. Taurine, an amino acid, was recently found to extend the lifespan of mice by 10%, as well as boosting a whole range of functions in the middle-aged rodents including muscle strength, endurance, coordination and insulin sensitivity. A major study in the journal Science published last year linked lower taurine levels to age-related problems, noting that blood levels of taurine in elderly humans are 80% lower than they were when they were younger. The attention such revelations generated has made taurine a popular dietary supplement among the legion of alternatives.</p>



<h3 class="wp-block-heading">Counter evolutionary?</h3>



<p>Extreme do-it-yourself lifespan extension, however, goes against the grain of evolution, which is more interested in reproduction rather than longevity. It is thought that increased lifespan comes at the cost of reduced fertility. Our bodies contain trillions of cells that will ultimately need rejuvenation or renewal – something which is incredibly difficult to overcome as evolution has little interest in keeping the repair system going.</p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/03/William-Shatner-820x1024.jpg" alt="" class="wp-image-80828" width="410" height="512" srcset="https://www.gafencushop.com/wp-content/uploads/2024/03/William-Shatner-820x1024.jpg 820w, https://www.gafencushop.com/wp-content/uploads/2024/03/William-Shatner-224x280.jpg 224w, https://www.gafencushop.com/wp-content/uploads/2024/03/William-Shatner-768x960.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/03/William-Shatner-200x250.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/03/William-Shatner-800x1000.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/03/William-Shatner.jpg 1026w" sizes="(max-width: 410px) 100vw, 410px" /></figure></div>


<p>So perhaps we should turn to the original Star Trek actor, William Shatner, who is now in his early 90s, for advice on staying young. He told Newsmax: “Say yes to the opportunity life is offering. Say yes to life, yes to dinner, yes to going out, and yes to something new.”</p>


The Elixir of Life: In the modern quest for eternal youth, the path is more medical science than myth


<p>While the benefits of drinking plenty of water are widely known, especially in terms of keeping the body hydrated, the health advantages of drinking water that has been enriched with hydrogen are only just being recognised. There is mounting scientific evidence to suggest the gas brings all sorts of gains that tap or bottled water cannot provide alone.</p>



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<p>Hydrogen is the lightest element in the periodic table and when bonded together forms molecular hydrogen (H2). Being the lightest and smallest of molecules, it can escape out of practically anything. It is an odourless, colourless and tasteless gas molecule, imperceptible by human senses. It binds to other elements like oxygen (creating water), nitrogen and carbon to form compounds.</p>



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<p>An interesting point is that about 10 percent of the weight of living organisms is hydrogen within water, proteins and fats. On a broader level, much of the vitality of our planet is derived from hydrogen since the energy emanating from the sun is a result of hydrogen being converted into helium.</p>



<h3 class="wp-block-heading">Therapeutic effects</h3>



<p>Studies have indicated that water (H2O, two hydrogen atoms bonded to an oxygen atom) containing dissolved hydrogen gas at a concentration of 0.5 to 1.6 mg/L (ppm) can provide therapeutic effects to the human body that plain water cannot deliver – apparently because the body cannot effectively absorb the hydrogen molecules attached to the oxygen molecules within water.</p>


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<figure class="aligncenter size-large"><img decoding="async" loading="lazy" width="1024" height="571" src="https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Plant-1024x571.jpg" alt="" class="wp-image-80492" srcset="https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Plant-1024x571.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Plant-502x280.jpg 502w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Plant-768x428.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Plant-1536x857.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Plant-2048x1142.jpg 2048w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Plant-200x112.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Plant-800x446.jpg 800w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure></div>


<p>Hydrogen-rich water made by infusing hydrogen gas into pure water is considered suitable as a health and preventative drink for people of all ages. It is believed that it is virtually impossible to overdose on molecular hydrogen and it has no toxic effects on living cells at high levels.</p>



<h3 class="wp-block-heading">H2 water everywhere</h3>



<p>H2 is often packed into cans or pouches, or can be made at home via special hydrogen water machines. H2 water machines and generator bottles are quite common in health clinics in Hong Kong and are a simple and effective way of ingesting molecular hydrogen.</p>



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<p>Portable hydrogen bottles are designed to infuse additional hydrogen molecules into drinking water and enrich it instantly, while counter-top hydration machines can produce therapeutic concentrations in greater quantities. H2 tablets can generate high levels of hydrogen in any water-based drink. It is also possible to take hydrogen baths and spray it onto your face.</p>



<h3 class="wp-block-heading">Antioxidant boost</h3>



<p>Molecular hydrogen has been generating such interest as it is thought to be a powerful antioxidant. Most pertinently, it is believed to have the ability to limit free-radical damage in the body. Free radicals are unstable molecules produced in the body and can be exacerbated by environmental factors. They can contribute to oxidative stress – a situation known to cause many health issues. Put simply, this is where free radicals attack healthy cells and cause irreversible damage.</p>


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<figure class="aligncenter size-large"><img decoding="async" loading="lazy" width="1024" height="576" src="https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Product_Elevate_01-1024x576.jpg" alt="" class="wp-image-80494" srcset="https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Product_Elevate_01-1024x576.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Product_Elevate_01-498x280.jpg 498w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Product_Elevate_01-768x432.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Product_Elevate_01-1536x864.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Product_Elevate_01-2048x1152.jpg 2048w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Product_Elevate_01-200x112.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/02/Hydrogen-Product_Elevate_01-800x450.jpg 800w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure></div>


<p>One of the best ways to combat oxidative stress is by upping your antioxidant defence system. The body naturally delivers antioxidant agent chemicals that destroy a multitude of free radicals. There are numerous ways to increase levels, such as a diet rich in antioxidant foods like fruit and veg, and by enjoying a healthy lifestyle – plus harnessing the benefits of hydrogen molecules.</p>



<h3 class="wp-block-heading">Small is beneficial</h3>



<p>According to some medical professionals, H2 has the properties to make it the best antioxidant of them all. The fact that the molecules are extremely small is important because for antioxidants to work effectively they must be able to penetrate cell areas being attacked by free radicals, and these are often difficult to reach. As H2 is in a gaseous state, it percolates through the body via rapid diffusion and is not blocked by mechanisms that ordinarily prevent other antioxidants from moving freely. And since H2 is not only small but exceedingly light, its ability to travel through cell layers is enhanced.</p>



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<p>Another great benefit of H2 as an antioxidant is that it is thought to produce zero byproducts, meaning it has zero toxicity and will even convert free radicals to water. Molecular hydrogen also has the ability to select and act upon free radicals that cause the most cell damage – an important attribute given that not all free radicals are thought to be harmful.</p>



<h3 class="wp-block-heading">Novel therapies</h3>



<p>Numerous studies point to the healing qualities of hydrogen-rich water. One eight-week study involving patients receiving radiation therapy for liver cancer showed decreased levels of oxidative stress for those participants who drank 51 to 68 ounces of water infused with hydrogen per day. Another research project conducted by the University of Western Ontario found consumption of hydrogen-rich water improved levels of oxidative-stress markers associated with metabolic syndrome – whose risk factors include obesity, high cholesterol, hypertension and insulin resistance – and boosted the body’s antioxidant activity. Researchers noted that hydrogen water represents a potentially novel therapeutic and preventive strategy for the treatment of metabolic syndrome.</p>



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<p>While molecular hydrogen is considered by some health professionals to be one of the best ways of fighting free radicals and limiting oxidative stress, other studies have reported less conclusive results. Further research is needed to assess the potential benefits with a higher level of scientific backing.</p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/02/1-1-1024x576.jpg" alt="" class="wp-image-80495" width="768" height="432" srcset="https://www.gafencushop.com/wp-content/uploads/2024/02/1-1-1024x576.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/02/1-1-498x280.jpg 498w, https://www.gafencushop.com/wp-content/uploads/2024/02/1-1-768x432.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/02/1-1-1536x864.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2024/02/1-1-2048x1152.jpg 2048w, https://www.gafencushop.com/wp-content/uploads/2024/02/1-1-200x112.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/02/1-1-800x450.jpg 800w" sizes="(max-width: 768px) 100vw, 768px" /></figure></div>


<p>Some scientists believe that molecular hydrogen can help in the battle against diseases of the immune system, such as lupus (SLE) and other types of immune-compromising infections. A Japanese study postulated that H2-rich water can combat rheumatoid joint pain by lessening oxidative pressure, and other findings have suggested molecular hydrogen dampens the allergic response when the immune system goes into overdrive. Furthermore, a study on rodents with Alzheimer’s disease indicated H2 can enhance cognitive functions and increase memory.</p>



<h3 class="wp-block-heading">Beauty bonus</h3>



<p>Though research is ongoing, there is evidence that molecular hydrogen can also work wonders as a beauty remedy. A Japanese study, among others, has shown that washing the face with hydrogen- infused water over a three-month period enhances skin elasticity and reduces wrinkles, promoting a youthful appearance. Other research has involved patients being administered hydrogen water directly into their veins via a saline drip, resulting in improvements in skin health.</p>



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<p>There is also evidence that hydrogen-rich water quickens athletes’ ability to recuperate from injury and boost their athletic performance.</p>


Healing Hydrogen: A profusion of health benefits may arise from sipping water infused with H2


<p>It is more than 60 years since the first evidence emerged of the existence of stem cells and their natural ability to renew and differentiate into specialised cells types, such as those governing the blood, brain, heart or bones. Two Canadian scientists happened to observe colonies of proliferating blood cells after injecting bone marrow cells into mice. Given that the rodents’ blood cells were able to regenerate fully, exciting potential medical benefits for humans were suddenly envisaged.</p>



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<p>Stem cells are considered the body’s master cells – the raw materials or primitive cells from which all other cells originate. Crucially, in the right conditions, be it in the body or a laboratory, stem cells can be split into daughter cells that are able to form new stem cells or, through differentiation, morph into specialised cells that have more specific functions.</p>



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<p>Stem cell research offers an advanced method of studying the function of genes and physiological processes, yet the really interesting and far-reaching consequences of the original findings in 1961 are the vast range of possible clinical applications. As well as shedding light on the origins of cancer, stem cells can potentially drive therapies for the treatment of diabetes, spinal cord injury, heart disease, Alzheimer’s disease, Parkinson’s disease and more.</p>



<h3 class="wp-block-heading">Government warning</h3>



<p>Stem-cell therapies replace ailing patients’ damaged tissues using stem cells (or their daughter cells). Such treatments involve advanced therapy medicinal products (ATMPs) – medicines based on genes, tissues or cells – and are considered high- risk. In many countries, they fall under statutory regulations and citizens are advised to be wary of unproven cell-based therapies offered by some clinics around the world.</p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/01/1-1-1024x736.jpg" alt="" class="wp-image-80127" width="768" height="552" srcset="https://www.gafencushop.com/wp-content/uploads/2024/01/1-1-1024x736.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/01/1-1-390x280.jpg 390w, https://www.gafencushop.com/wp-content/uploads/2024/01/1-1-768x552.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/01/1-1-1536x1104.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2024/01/1-1-200x144.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/01/1-1-800x575.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/01/1-1.jpg 1565w" sizes="(max-width: 768px) 100vw, 768px" /></figure></div>


<p>In Hong Kong, no ATPMs in the stem-cell category are registered for use. The Department of Health’s Drug Office warns that the safety, efficacy and quality of any unregistered medicines using stem-cell technology cannot be guaranteed. Certain cell or tissue replacement therapies like blood transfusion and bone marrow and cornea transplants, however, do not fall under this category and are commonly practised.</p>



<h3 class="wp-block-heading">Dangerous hype</h3>



<p>The potential to replace damaged tissue through regenerative medicine has fascinated the scientific community for decades. For laypeople who read about stem cells being coaxed into multiplying and populating different tissues, it may seem like a wonder cure for all debilitating conditions. This wild speculation has been fuelled by apparently successful cases being claimed and blown out of proportion before rigorous scientific process has been conducted.</p>



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<p>A particularly notorious case involved Italian thoracic surgeon Paolo Macchiarini, who in 2008 created a new airway for Claudio Castillo, a young woman from Barcelona, using stem cells taken from her own bone marrow. These were implanted into a windpipe taken from a deceased donor, and stripped of its cells to leave a bare scaffold. Since the treatment involved the patient’s own cells, it appeared that her immune system was able to accept the replacement windpipe without the necessity of immune-suppressing drugs. The organ seemed to function like it was Castillo’s own, and the procedure was reported in the press as a miraculous breakthrough.</p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/01/3-1-1024x799.jpg" alt="" class="wp-image-80130" width="768" height="599" srcset="https://www.gafencushop.com/wp-content/uploads/2024/01/3-1-1024x799.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/01/3-1-359x280.jpg 359w, https://www.gafencushop.com/wp-content/uploads/2024/01/3-1-768x599.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/01/3-1-200x156.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/01/3-1-800x624.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/01/3-1.jpg 1422w" sizes="(max-width: 768px) 100vw, 768px" /></figure></div>


<p>But this lofty claim was not justified. Many of the 17 or more patients around the world whom Macchiarini treated with artificial or regenerating windpipes suffered severe complications and subsequently died. His career and reputation unravelled, causing much soul-searching into the dangers of overhyping the progress of stem-cell therapy.</p>



<h3 class="wp-block-heading">Questions of immunity</h3>



<p>This case generated so much interest partly because it was perceived that patients could be treated with stem cells taken from their own bone marrow. Many such treatments have not worked, though the notable exception is blood stem-cell transplantation, which has been used on people with leukaemia and other cancers of the blood for decades, saving countless lives.</p>



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<p>A recent report in the New Scientist detailed the treatment of diabetes in mice using genetically altered cells that bypass the immune system. Pioneered by Californian firm Sana Biotechnology, the method uses pancreas cells formed from stem cells that do not cause a destructive immune response. This is crucial because most stem-cell therapies in development require either the taking of immune suppressors or the use of stem cells derived from the person receiving them – which is costly, time-consuming and lacks universality. Cells from one person that are put into another usually provoke an immune response.</p>



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<p>Sana Biotechnology bypassed this issue by genetically creating cells so they become invisible to the immune system. In tests using rhesus macaques, pluripotent versions of these cells – which have the potential to be turned into multiple different tissues and organs – survived with no sign of an immune attack for up to four months. By contrast, cells inserted into the monkeys without genetic changes were destroyed by their immune system within four weeks.</p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2024/01/2-1-1024x774.jpg" alt="" class="wp-image-80128" width="768" height="581" srcset="https://www.gafencushop.com/wp-content/uploads/2024/01/2-1-1024x774.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2024/01/2-1-370x280.jpg 370w, https://www.gafencushop.com/wp-content/uploads/2024/01/2-1-768x581.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2024/01/2-1-1536x1161.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2024/01/2-1-200x151.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2024/01/2-1-800x605.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2024/01/2-1.jpg 1586w" sizes="(max-width: 768px) 100vw, 768px" /></figure></div>


<p>Blood tests indicated that the stem-cell-derived pancreas cells used to treat the mice for type 1 diabetes helped to reduce their diabetes symptoms. This research could be an important step towards off-the-shelf stem-cell treatment for a whole range of conditions including heart attacks and strokes. As Sana Biotechnology’s Sonja Schrepfer put it: “The vision is we have cells for anyone, anytime, anywhere.”</p>



<h3 class="wp-block-heading">Future vision</h3>



<p>In a concerted effort to combat degeneration of the eye, Dr Chien-Ling Huang and her research team at the Hong Kong Polytechnic University’s Department of Health Technology and Informatics are utilising induced pluripotent stem cells (iPSCs), a unique manipulable cell type that can be obtained by reprogramming animal and human differentiated cells. The team not only harnessed the versatility of iPSCs but also refined the differentiation process, coaxing these cells into distinct lineages vital for blood circulation and the intricate structure of the retina.</p>



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<p>Imitating nature, their approach involves crafting an artificial extracellular matrix, a scaffold providing structural and biochemical support for cell growth. They believe the innovation not only improves retinal neuron differentiation efficiency but also lays the groundwork for further advancements in regenerative medicine. “Through the strategic integration of state- of-the-art gene editing and advanced biomaterials, the team envisions a significant enhancement in the generation of specific cell types crucial for combating degenerative conditions,” said a spokesperson.</p>



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<p>Dr Huang’s team indicated that they remain focused on the ultimate goal: to contribute significantly to the arsenal of medical interventions aimed at saving individuals from the grips of degeneration disorders.</p>


Stem The Tide: Though no cure-all, stem cell therapy offers hope for a range of debilitating conditions


<p>Two great gadgets designed to bring joy – a bike with enhanced features that will make any workout a sheer delight and a camera that can save and print digital images.</p>



<h3 class="wp-block-heading">Instant Print</h3>



<p><em>Shots that leave a legacy</em></p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2023/12/Leica_Sofort2_front_red_LoRes_sRGB-copy_p-1024x1024.jpg" alt="" class="wp-image-79873" width="512" height="512" srcset="https://www.gafencushop.com/wp-content/uploads/2023/12/Leica_Sofort2_front_red_LoRes_sRGB-copy_p-1024x1024.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2023/12/Leica_Sofort2_front_red_LoRes_sRGB-copy_p-280x280.jpg 280w, https://www.gafencushop.com/wp-content/uploads/2023/12/Leica_Sofort2_front_red_LoRes_sRGB-copy_p-768x768.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2023/12/Leica_Sofort2_front_red_LoRes_sRGB-copy_p-1536x1536.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2023/12/Leica_Sofort2_front_red_LoRes_sRGB-copy_p-2048x2048.jpg 2048w, https://www.gafencushop.com/wp-content/uploads/2023/12/Leica_Sofort2_front_red_LoRes_sRGB-copy_p-200x200.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2023/12/Leica_Sofort2_front_red_LoRes_sRGB-copy_p-800x800.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2023/12/Leica_Sofort2_front_red_LoRes_sRGB-copy_p-100x100.jpg 100w" sizes="(max-width: 512px) 100vw, 512px" /></figure></div>


<p>Leica have updated their printed photo and camera specifications with the Sofort 2, an enhanced version of the Leica Sofort 1 which has proved such a resounding success. This new product has just come onto the market and looks set to offer camera consumers additional benefits for those who love instant printed photos. The love affair with instant prints took off in the 1970s and 1980s, and though the onset of the digital age seemed to push the instant print to the sidelines temporarily, the demand endures and this new hybrid model offers the advantage of combining both digital and analogue technology with greater flexibility.</p>



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<p>The Leica Sofort 2 enhanced features allow users to permanently save digital images and choose the best photos before making the plunge to print them. This facility is available for all photos taken on your smartphone as well those shot with other Leica cameras and stored in the Leica FOTOS App containing a gallery of shots. Sofort 2 weighs 320 grams and has a RGB colour filter, its file size is around 1.2MB and has an image output time of around 16 seconds.</p>
</div><figure class="wp-block-media-text__media"><img decoding="async" loading="lazy" width="756" height="756" src="https://www.gafencushop.com/wp-content/uploads/2023/12/discover_hero_3840x1780_p.jpg" alt="" class="wp-image-79871 size-full" srcset="https://www.gafencushop.com/wp-content/uploads/2023/12/discover_hero_3840x1780_p.jpg 756w, https://www.gafencushop.com/wp-content/uploads/2023/12/discover_hero_3840x1780_p-280x280.jpg 280w, https://www.gafencushop.com/wp-content/uploads/2023/12/discover_hero_3840x1780_p-200x200.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2023/12/discover_hero_3840x1780_p-100x100.jpg 100w" sizes="(max-width: 756px) 100vw, 756px" /></figure></div>



<p>The camera is available in black, red or white options and offers a range of fun features to aid the creative process. The camera also has numerous accessories such as wooden picture frames to showcase the prints. Costs US$389.</p>



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<h3 class="wp-block-heading">Pedal Power</h3>



<p><em>Cycle your way to pleasure</em></p>


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<figure class="aligncenter size-large is-resized"><img decoding="async" loading="lazy" src="https://www.gafencushop.com/wp-content/uploads/2023/12/S-Peloton-Bike-Plus_-Elevate-your-fitness-with-Peloton-1-copy-2-1024x1024.jpg" alt="" class="wp-image-79874" width="512" height="512" srcset="https://www.gafencushop.com/wp-content/uploads/2023/12/S-Peloton-Bike-Plus_-Elevate-your-fitness-with-Peloton-1-copy-2-1024x1024.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2023/12/S-Peloton-Bike-Plus_-Elevate-your-fitness-with-Peloton-1-copy-2-280x280.jpg 280w, https://www.gafencushop.com/wp-content/uploads/2023/12/S-Peloton-Bike-Plus_-Elevate-your-fitness-with-Peloton-1-copy-2-768x768.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2023/12/S-Peloton-Bike-Plus_-Elevate-your-fitness-with-Peloton-1-copy-2-1536x1536.jpg 1536w, https://www.gafencushop.com/wp-content/uploads/2023/12/S-Peloton-Bike-Plus_-Elevate-your-fitness-with-Peloton-1-copy-2-2048x2048.jpg 2048w, https://www.gafencushop.com/wp-content/uploads/2023/12/S-Peloton-Bike-Plus_-Elevate-your-fitness-with-Peloton-1-copy-2-200x200.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2023/12/S-Peloton-Bike-Plus_-Elevate-your-fitness-with-Peloton-1-copy-2-800x800.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2023/12/S-Peloton-Bike-Plus_-Elevate-your-fitness-with-Peloton-1-copy-2-100x100.jpg 100w" sizes="(max-width: 512px) 100vw, 512px" /></figure></div>


<p>The Peloton Bike+ has incorporated improved features allowing those keen to get in their full resistance and endurance training every opportunity to push themselves to the limit in style and without any hindrance. For instance, the ability of a new and much larger touchscreen to swivel outwards allows someone keen to combine workouts the opportunity to undertake other strength and cardio routines.</p>



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<p>The speakers are also of higher quality, such that the effect of these powerful built-in speakers is to make those engaged in heart-pumping activity feel closer to the action and the enhanced quality can cancel out all distractions, meaning the user is supremely focused on the activity class during sweaty workouts. In addition, an automatic resistance setting reduces the need to think about making correct settings and allows users to train stress-free.</p>
</div><figure class="wp-block-media-text__media"><img decoding="async" loading="lazy" width="1024" height="1024" src="https://www.gafencushop.com/wp-content/uploads/2023/12/111-1024x1024.jpg" alt="" class="wp-image-79877 size-full" srcset="https://www.gafencushop.com/wp-content/uploads/2023/12/111-1024x1024.jpg 1024w, https://www.gafencushop.com/wp-content/uploads/2023/12/111-280x280.jpg 280w, https://www.gafencushop.com/wp-content/uploads/2023/12/111-768x768.jpg 768w, https://www.gafencushop.com/wp-content/uploads/2023/12/111-200x200.jpg 200w, https://www.gafencushop.com/wp-content/uploads/2023/12/111-800x800.jpg 800w, https://www.gafencushop.com/wp-content/uploads/2023/12/111-100x100.jpg 100w, https://www.gafencushop.com/wp-content/uploads/2023/12/111.jpg 1190w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure></div>



<p>The monitor offers a variety of classes with different instructors and other classes such as yoga, boxing and weights are options using the range of accessories. Users can connect to live classes in other parts of the world such as Sydney, New York and London and feel the warmth of the community. Other additional features include an upgraded front-facing camera from 5MP to 8MP, a slightly changed handlebar design and power cables are now all internally routed. Price from US$2,040.</p>


Tag: wellness